Apoptosis: A Key Alternate Trigger of Carcinogenesis
Chanda Siddoo-Atwal, President and Primary Biochemist of Moondust Cosmetics Ltd., explores apoptosis, a key alternate trigger of carcinogenesis
Around the time that I discovered a landmark paper on skin cancer showing that simply elevating the rate of cell death (Apoptosis) in mouse skin could result in squamous cell carcinoma (1), I was observing that sunscreens (despite increasing SPF levels) did not block sunburn on my own skin and that it was still subject to peeling (or apoptosis) following sun exposure. This was disconcerting to me as a cancer biologist since sunscreen is supposed to help prevent skin cancer and such papers demonstrated definitively that cell death (apoptosis) in response to a complete carcinogen such as UVA/UVB is directly linked to carcinogenesis. Therefore, firstly, I elucidated the three steps in the Human Sunburn Cycle – 1. Redness and inflammation; 2. New tissue formation; and 3. Apoptosis (2).
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